Please choose your shipping country in order to get correct prices and freight cost.

Africa
America
Asia
Europe
Oceania
  • |
  • Current Country: United States
Dextran Application Area Lyophilization

Lyophilization

Dextran used as Excipient in Lyophilization (freeze-drying)

Lyophilization is a commonly used technique for formulation development of small molecules, proteins and vaccines which are unstable in aqueous medium and/or are thermolabile in nature. Lyophilization of drug alone, however, presents certain formulation development challenges, which may be overcome by incorporation of excipients in the formulation. Dextran is often used as excipient during lyophilization as a bulking agent and/or a collapse temperature modifier.
(A. Baheti, L. Kumar, A. Bansal. J. Excipients and Food Chem. 1 (1) 2010, p. 41-54).

Lyophilization techniques are also used in order to improve the dissolution rate and oral bioavailability of drugs with poor solubility and high permeability as well as for Fast Disintegration Tables (FDT) Link

 

Dextrans used in Lyophilization

Different fractions of dextran have been used for Lyophilization e.g. Dextran 1Dextran 10Dextran 40Dextran 70 and Dextran 110

 

Dextran Thumb 1Dextran Thumb 10Dextran Thumb 40Dextran Thumb 70Dextran Thumb 110

Examples of Branded Products Containing Dextran

MYLOTARG/GEMTUZUMAB
Pfizer (Wyeth)   
Chemotherapy (Antibody)          
IV         
Dextran 40
Link to product

ROTARIX          
GSK Biologicals            
Lyo oral vaccine vs. Gastroenteritis           
Oral      
Dextran 1            
Link to product

SPASFON LYOC  
TEVA (Cephalon)                      
Oral      
Dextran 70  
Link to product

ETOPOPHOS
Bristol-Myers Squibb
Chemotheraphy
Dextran 40
Link to product

LIOTHYRONINE
Amdipharm
LiothyronineTreatment of myxoedema coma
Dextran 110
Link to product 

 

 

Order Online

Pay by Visa, MasterCard or bank transfer

Action

Get Documentation

Download certificates and documentation.

Action

Contact Specialist


Anne-Marie J. Ørkild

Director, International Sales and Business Carbohydrates

Phone: +45 5948 5959
E-mail: dextran@pharmacosmos.com

Approved

Pharmacosmos is the only dextran manufacturer holding certificates from the US FDA and European Directorate for the Quality of Medicines (EDQM)

Read more

Quality Delivered

Pharmacosmos delivers a unique dextran quality through a production technology that completely avoids the use of organic solvents and a quality system that meets the strictest cGMP standards for human medicines

Read more

Global Service

Pharmacosmos sells and ships directly to clients everywhere in the World. We deliver Pharmaceutical Quality Dextran of the highest standards, including those of the European Pharmacopoeia (EP), the United States Pharmacopoeia (USP), and the Japanese Pharmacopoeia (JP).

Read more