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Dextran Chemistry

Dextran Structure

Dextran Structure

Dextran is an α-D-1,6-glucose-linked glucan with side-chains 1-3 linked to the backbone units of the Dextran biopolymer. The degree of branching is approximately 5% in native (unfractionated) dextran and decreases with decreasing molecular weight. The branches are mostly 1-2 glucose units long.

Dextran can be obtained from fermentation of sucrose-containing media by Leuconostoc mesenteroides B512F.

A fragment of the Dextran structure is illustrated in Figure 1.

Ill 04

Fig. 1: Dextran is a glucose polymer in which the linkages are predominantly of the α(1,6) type. The degree of α(1,3) branching is generally less than 5% and decreases with decreasing molecular weight

 

 

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Pharmacosmos delivers a unique dextran quality through a production technology that completely avoids the use of organic solvents and a quality system that meets the strictest cGMP standards for human medicines

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