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Dextran Chemistry Biocompatibility


The clinical use of Dextrans over the past 50 years provides impressive proof of their safety and quality. Most of the safety studies have been related to parenterally administered Dextran solutions in the molecular weight range 40,000 (Dextran 40) to 70,000 (Dextran 70). The intravenous mean lethal dose of Dextran 70 fraction is 55 g/kg bodyweight in mice, 18 g/kg bodyweight in rabbits, and 10 g/kg bodyweight in dogs.

Dextran may be ingested orally and is well tolerated. The ingestion of Dextran is followed by a rapid increase in blood sugar and liver glycogen and is thus digestible.

Many other applications of Dextran in medicine have appeared. Dextran is an ingredient of solutions for ophthalmic use, for intrauterine examinations, and is also used in creams and ointments. It may therefore be concluded that Dextran has an excellent record of biocompatibility.

Pharmacosmos is a manufacturer of Pharmaceutical Quality Dextran including Dextran 1Dextran 40Dextran 60, and Dextran 70 according to pharmacopoeial specifications, for example EP, USP, and JP.


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Pharmacosmos is the only dextran manufacturer holding certificates from the US FDA and European Directorate for the Quality of Medicines (EDQM)

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Quality Delivered

Pharmacosmos delivers a unique dextran quality through a production technology that completely avoids the use of organic solvents and a quality system that meets the strictest cGMP standards for human medicines

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Global Service

Pharmacosmos sells and ships directly to clients everywhere in the World. We deliver Pharmaceutical Quality Dextran of the highest standards, including those of the European Pharmacopoeia (EP), the United States Pharmacopoeia (USP), and the Japanese Pharmacopoeia (JP).

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